The upcoming NFL matchup on November 2, 2025, features the San Francisco 49ers taking on the New York Giants at MetLife Stadium in East Rutherford, scheduled for a 1:00 PM kickoff.

In last year’s NFL standings, the San Francisco 49ers held the top spot in their division and the second in their conference, boasting a record of 3-1-0 and a 0.75 winning percentage. They scored 80 points against 75 allowed, resulting in a +5 net point difference.

Meanwhile, the New York Giants were 4th in their division and 15th in the conference, with a 1-3-0 record and a 0.25 winning percentage. They scored 73 points while giving up 101, marking a -28 net point difference.

In their recent outings, the 49ers were defeated 18-28 by Kansas City at Levi’s Stadium, amassing 19 first downs with 101 rushing yards and 209 passing yards. Conversely, the Giants lost 3-28 to Philadelphia, managing 10 first downs, 76 rushing yards, and just 43 passing yards.

Quarterback statistics from the previous games highlight Brock Purdy of the 49ers with 212 passing yards, a passer rating of 36.69, and Daniel Jones of the Giants who threw for 99 yards with a passer rating of 77.28.

Odds Analysis: The betting odds for this game demonstrate clear expectations. The Giants are at a home point spread of +3.50, suggesting that odds-makers believe they are underdogs by that margin. The 49ers, commanding a -3.50 away point spread, are expected to win by more than a field goal. The over/under set at 44.70 points indicates anticipation of a moderately high-scoring game. For straight winners, moneyline odds have the Giants at +161 and the 49ers at -193, reinforcing the view of their favored status.

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