On October 19, 2025, at 4:05 PM, the New York Giants are set to battle the Denver Broncos at Empower Field at Mile High in Denver. Last season, the Giants wrapped up fourth in their division and 15th in the NFC, with a 1-3-0 record, a 0.25 win rate, 73 points for, and 101 points against, leading to a -28 point differential. The Broncos, meanwhile, were third in their division and ninth in the AFC with a record of 1-2-0, a 0.33 win rate, 68 points for, 64 against, and a net point differential of 4. In their previous encounters, the Giants, hosting the Cincinnati Bengals, concluded the game at 7-17, capturing 24 first downs, alongside 119 rushing and 190 passing yards. The Broncos faced the Los Angeles Chargers at home, ending the match at 16-23, with 17 first downs, 110 rushing yards, and 206 passing yards. A noteworthy performance by Giants’ Daniel Jones included 205 passing yards but yielded no touchdowns with a rating of 57.47, while Broncos’ Bo Nix tallied 216 yards passing, two touchdowns, and a passer rating of 84.91. The adeptness of both quarterbacks suggests a thrilling confrontation is on the horizon. For the latest updates on this game and more, keep an eye on betLouisianasports.com. When it comes to betting, the home team Denver Broncos have been set with a point spread of -8.00, indicating they are the favorites. The away team New York Giants carry a point spread of +8.60, reflecting the underdog role. The total points (over/under) for the matchup is anticipated to be 45.60. Moneyline odds are decidedly in favor of Denver at -381, with the Giants positioned at +300, suggesting analysts expect a stronger performance from the Broncos.